Successful Treatment of Vitiligo by Needling with Topical 5 Fluorouracil

Introduction: Vitiligo is a chronic acquired disorder presenting with depigmented macules and patches. The response to treatment is variable as no single therapy produces predictably good results. Needling with topical 5% 5 fluorouracil in vitiligo has been found to be promising, effective and safe modality of treatment. Materials and methods: Three patients with stable vitiligo were on medical treatment and phototherapy for two to three years. All the patients were not satisfied in terms of repigmentation. They were subjected to needling with topical 5% 5 fluorouracil application every 2 weeks for three months, along with their ongoing therapy. Results: All the patients showed >75% improvement in terms of repigmentation of the achromic patches. Conclusion: This method of needling with application of 5 fluorouracil cream is simple, safe and cost effective method for treating patients with stable vitiligo.